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List of research infrastructures

Infrastructure resources at Lund University.

Our facilities provide the opportunity to study protein structure, molecular probes and drug design, system biology and molecular interactions in cells and tissues. Thanks to our world class research infrastructure, Lund University is well equipped to help lead the way towards future scientific breakthroughs.

Below is a non-exhaustive list of in-house infrastructures that are categorized into three overarching themes: bio-imaging, proteins, genes & cells and other resources.


Bio-Imaging

Our facilities provide the opportunity to study molecules, cells, organs and entire organisms.


Proteins

With the help of various forms of mass spectrometry, synchrotron radiation, protein production & labelling, and bioinformatics, our facilities provide the opportunity to study protein structure and dynamics, molecular probes and drug design. Below you can see some examples of the infrastructure for proteins, available for researchers at Lund University.


Genes & Cells

Our facilities provide the opportunity to study molecular probes, system biology and molecular interactions in cells and tissues.Below you can see some examples of the infrastructure for research on genes and cells, available for researchers at Lund University.


Other resources

In addition to infrastructures for bioimaging, protein and genes & cells, we also provide other resources e.g., databases, networks and specialized labs.


List of infrastructures in alphabetical order


Anterior chamber of the eye (ACE) platform

ACE

 

Direct visualization in a variety of tissues transplanted into the anterior chamber of the eye (ACE) provides a platform to screen drugs by performing long-term follow up and monitoring in target tissues. For access to competence and instruments please contact the ACE platform.


Adeno Associated Vector platform

AAV

 

Our Adeno-Associated Vector (AAV) platform offers development, design and production of AAV vectors. AAV vectors can be used for the establishment of disease models, experimental gene therapy and basic experimental research of brain functions. The AAV-facility is open to internal LU-users as well as external users from other universities and industry.

Read more: AAV Vector Lab


Biacore X100 - Surface Plasmon Resonance

 

Biacore

 

The Biacore X100 instrument is open for external users to hire after completed course or we can provide a full service.

The Biacore X100 uses the surface plasmon resonance (SPR) technique to monitor molecular interactions in real time. The procedure is as follows; one of the interacting molecules (the ligand) is attached to a surface of a sensor chip, and the other interacting molecule (analyte) is injected and will flow over the sensor chip. If any binding occurs between the ligand and the analyte, the refractive index will change at the sensor surface, that is proportional to the change in mass concentration, and association and dissociation rates of the interaction may be determined.

Read more: Biacore X100- Surface Plasmon Resonance


BioMAX at MAX IV

Electron density map of the cofactor NADP bound to FabG. Courtesy of Robert Schnell, Karolinska Institutet
Electron density map of the cofactor NADP bound to FabG. Courtesy of Robert Schnell, Karolinska Institutet

BioMAX is the first X-ray macromolecular crystallography beamline of MAX IV Laboratory. It is a state-of-the-art resource accommodating multiple cutting edge experimental possibilities. The beamline experiment set-up is highly automated, in terms of both sample handling hardware and data analysis.

Due to its extensive energy tunability, BioMAX is an ideal source for de novo phasing using the anomalous signal of heavy elements. The small beam cross-section and parallel beam makes BioMAX suitable for X-ray crystallography using microcrystals and ultra large unit cells.

Read more: BioMAX at MAX IV


CBT Small Molecule Screening infrastructure


The CBT (Chemical Biology & Therapeutics) small molecule screening infrastructure enables the use of screening technology as well as expertise and reagents to help researchers at Lund University towards new discoveries in fundamental aspects of biology. The infrastructure is not limited to drug discovery but can be used by any researcher to quickly conduct hundreds of biochemical, genetic or pharmacological tests. The library contains annotated molecules with known biological activities, a powerful tool to identify novel mechanisms and pathways, several of the molecules are approved drugs or molecules that have been in the clinic, which might facilitate translation of early discoveries to human studies. In addition, included are also non-target biased commercial compounds and academic compounds, in total 10000 compounds.

Contact: Roger [dot] Olsson [at] med [dot] lu [dot] se


Cellomics and Flow Cytometry Core Facility at MultiPark

 

Screening/Analysis and FACSAria III are open to external users.
The Cellomics Array Scan is a high throughput system for acquisition and screening of Fluorescence Microscopy images, applying automated image analysis of fluorescence intensities in cells, subcellular compartments or small organisms, e.g. zebrafish and nematodes. Our BD FACSAriaIII cell sorter is equipped with three lasers (blue, yellow/green, red) and can analyze up to ten fluorescent channels and sort up to four cell populations simultaneously.

Read more: FACS platform at MultiPark and Cellomics platform at MultiPark


CLEM at IQ Biotechnology Platform

CLEM
A scanning electron micrograph showing murine lung tissue.

CLEM stands for Correlative Light and Electron Microscope (CLEM) that allows the simultaneous analysis of specimens by fluorescence and scanning electron microscopy. With this new technology, you can combine immunological and three-dimensional information within the same image. 

CLEM is the perfect tool to analyze unknown ultrastructures with a fast result, and to unravel complex relationships between structural and functional biological questions. We help you through the process, from preparation to analysis.

Read more: www.med.lu.se/clem


CTG - Center for Translational Genomics

CTG

CTG is a research infrastructure and technical platform for Next Generation Sequencing (NGS) and other genomics technologies. CTG is part of the SciLifeLab infrastructure. We provide the following services:

  • Support in project planning
  • Guidelines for DNA and RNA extractions
  • Quality control and Library preparation (standard and customized)
  • Next Generation Sequencing (DNA and RNA)
  • Bioinformatics expertise

Read more about CTG


EpiHealth Cohort Study

epihealth

EpiHealth cohort study is a national resource investigating the interaction between genes and life-style factors regarding the development of common diseases seen in the elderly. At present (2017) it includes 25,000 Swedish men and women between the ages of 45 and 75 years, new subjects are recruited continously. It is an open-access resource accessible for all researchers.

The aim of the study is to map the causes of our most common diseases, like heart and vascular disease, cancer, osteoporosis, depressions, diabetes, obesity, dementia etc. The study includes data of cardiovascular status, lung and cognitive function and biobanking, lifestyle factors and environmental exposure.

Read more: Epihealth Cohort Study


Health Science Lab (at the Health Sciences Center and Gerdahallen)

HSC

At Health Sciences Center you can test:

  • Muscular function, strength and endurance with Biodex
  • Muscular activity with EMG
  • Submaximal exercise capacity on ergometer cycles
  • Physical activity with accelerometers

At Gerdahallen you can test:

  • Maximal exercise and submaximal exercise capacity on ergometer cycles or treadmill incl. measurements with ergospirometer.
  • ECG or heart rate monitored with Polar pulse equipment.
  • Analyze of running technique

To book at Health Science lab, contact: andy [dot] andersson [at] med [dot] lu [dot] se

To book at Gerdahallen, contact: ulf [dot] malmsten [at] gerdahallen [dot] com


Image Core Facility at Immunology

imagecore

The Section of Immunology provides users with advanced microscopes, image analysis software and technical support. The core facility is available for researchers at Lund University.

The facility includes:

  • Laser scanning confocal (LSM700)
  • Zeiss Axiovision
  • TIRF/ Spinning disc FLIM Inverted microscope (6 laser lines)

Contact: Lena_M [dot] Svensson [at] med [dot] lu [dot] se


IQ Biotechnology Platform

iqbiotech

IQ Biotechnology gives you access to a whole spectrum of services from experimental design, to gene-, protein- and in vivo- experiments and all the way to analysis.  IQ Biotechnology do: Imaging and quantification, experimental design, assay development,high throughput experiments, validation, and data analysis:

  • Immunochistochemistry 
  • Light and Electron Microscopy (TEM, SEM and CLEM)
  • Cell analysis - BioPlex
  • Cytokine  - Biacore
  • Gene expression - qPCR 

Read more about: IQ Biotechnology


LBIC - Lund University Bioimaging Center

LBIC combines knowledge in the fields of medical physics, preclinical and clinical medicine, chemistry and technology in order to provide and develop imaging methods for the advanced study of morphology, cellular metabolism and physiological function in health and disease.

Modalities offered at LBIC:

  • MRI
  • PET/SPECT/CT
  • TEM/SEM electron microscopy/super-resolution light microscopy
  • National 7T facility for ultra high-field human MRI research

LBIC also offers training, support, workshops and seminars.

Read more: Lund University Bioimaging Center


LP3 - Lund Protein Production Platform

lp3

A cross-faculty facility for protein production and purification with:

  • Cloning - design of a vector construct
  • Protein production in bacterial cells and insect cells
  • Protein labelling
  • Protein purification using chromatography equipment

At LP3 we exchange scientific ideas for dissemination and assimilation of new methodologies for protein production, purification and analysis. We also offer research training and development of skills in experimental protein science for PhD students and postdocs.

Read more: LP3 - Lund Protein Production Platform


LUPOP (Lund University Population Research Platform)

lupop

LUPOP is an open resource available for all researchers at Lund University. LUPOP provides support for population based research, such as advice on study design and scientific approaches, applications for funding and data access within population research, and ethical and legal issues. Through the website www.lupop.lu.se, researchers and students can keep updated with the latest within population based research. The website can also be used by researchers at Lund University to provide information to colleagues, students, media, and the public.

Read more: www.lupop.lu.se


MAX IV
Foto: Leif Jansson
MAX IV by night

 

The MAX IV Laboratory serves 1000 users per year and deliver science in a broad range of fields including structure and dynamics of proteins in solution, protein crystallography and biomedical imaging. Since summer 2016 the new world leadning synchotron facility, MAX IV is up and running.

Read more: MAX IV


MedMAX a future part of the MAX IV Laboratory in Lund

MedMAX – a future beamline inside MAX IV, which will help us to study events and processes in tissues and materials using accelerators producing x-rays of very high intensity. MedMAX will be a super-eye capable of helping us understand biomedical problems. With its help, we can find new ways of discovering, diagnosing and treating diseases such as cancer, diabetes and osteoporosis.

Read more about the campaign: MedMAX

Read more about MedMAX


MESO QuickPlex at MultiPark Platform

mesoquick

The MESO QuickPlex is a multiplexing plate reader using high-performance, electrochemiluminescence (ECL) immunoassays for detecting bio markers.

It is quick (90 seconds for one plate) and can handle many samples at the same time. The ECL system allows for detection with high sensitivity and wide dynamic range, which in combination with multi-array technology enables accurate measurements of multiple analytes in low sample volume. The instrument is easy to learn and use. There is more than 600 immunoassays for a range of applications including immunology, inflammation, oncology, neurobiology, and toxicology, in various assay formats.

Read more: MESO QuickPlex at MultiPark Platform


Microscopy Community at Lund University (MiCLU)

bacteria

MiCLU is promoting imaging with a special focuson correlative 3D imaging with microscopy and microscopic analysisat Lund University. The main role of MiCLU is to provide planning for goodaccess at Lund University to advanced equipment and methods in microscopy andmicroscopic analysis. MiCLU works to promote co-ordination and synergismof existing infrastructure resources and planning and applications for newresources.

For more information visit MiCLU webpage


MoReLife

MoreLife

A network named Molecular Recognition in Life (MoReLife) which aims to promote development and coordination of competences of use to life science researchers at Lund University. MoReLife is a trans-disciplinary network distributed over the faculties of Science, Medicine and Engineering. The focus is molecular Life Science:

  • Bioimaging and in vivo models
  • Systems biology and omics
  • Molecular Probes and drug design
  • Protein structure and recognition

Read more: MoReLife


Optical Projection Tomography - OPT

animation

  • Do you want to create high-resolution 3D images of large specimen like mouse pancreas, liver, kidney, spinal cord or brain?
  • Do you want to aquire flourescent images and map the distribution of a flourescent protein/molecule of interest?

Then our expertise in OPT imaging could help you to answer your scientific question.

Read more: OPT imaging platform


The Scania Metadatabase for Epidemiology

metadata

The Scania Metadatabase of Epidemiology is a catalogue with a description of several of the epidemiological studies that have been collected within Lund University and Region Skåne. The catalogue currently comprises 50 studies including a total of more than 670 000 study participants, as well as biological samples from about 20 studies.

The expectation is that the metadatabase will be used as an inspiration for new research and open up new research partnerships by visualizing the research groups and their publications.

Read more: Scania Metadatabase for Epidemiology 


StemTherapy FACS Core Facility

facs stemtherapy

Flow cytometry is one of the major methods used to analyze and sub-fractionate cells. It has major advantages such as the simultaneous detection of a wide range of parameters that enables the understanding of diversity among seemingly similar cells. The ability to enumerate large numbers of viable cells in a relatively short period of time provides experiment with reliability. At the Stem Therapy FACS Core Facility we have three cell FACS Aria sorters, that allow detection of up to 16 fluorescent probes, as well as two analysis machines: Fortessa and LSRII. We can help you through the whole process, from design of the experiment to the running of the experiment.

  • Assisted Cell sorting
  • Assisted FACS Analysis
  • Advice and supervision of users during experiments

Advice for experimental design and developing new protocols

Read more: StemTherapy FACS 


Tissue Micro Array Center

Kidney tissue stained with vimentin antibody.
Kidney tissue stained with vimentin antibody.

The TMA-center offers high quality immunohistochemistry staining of tissue. Sample preparation and processing, embedding, sectioning, staining and scanning of the stained slides. We provides both single staining (one protein) and double staining (two proteins) performed with an Autostainer (Agilent/DAKO) automated system. The stained slides are scanned using an Aperio scanner.

The TMA-center also assembles TMA-blocks. A TMA block (Tissue Micro Array) is a block consisting of small cores from up to 96 different samples/cancers/tissues all organized in one block.

Contact: kristina [dot] ekstrom-holka [at] skane [dot] se (Kristina Ekström-Holka)


Two-photon microscopy at BMC

photonmicroscope
Angela Cenci-Nilsson & Tim Fieblinger in the in vitro two-photon microscopy lab

This platform allows imaging of tissues with very high temporal and spatial resolution. It consists of two microscopy stations: an ‘in vivo’ setup is used to image dynamic processes in the life mouse and an ‘ex vivo’ system designed to image thick live preparations, such as tissues that are not accessible to ‘in vivo’ microscopy. Both systems are available for LU and external users.

Read more: Two-photon-microscopy


Contact

Kajsa M Paulsson

Kajsa M Paulsson

Coordinator Research Infrastructure

e-mail: kajsa_m [dot] paulsson [at] med [dot] lu [dot] se