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List of research infrastructures

Infrastructure resources at Lund University.

Our facilities provide the opportunity to study protein structure, molecular probes and drug design, system biology and molecular interactions in cells and tissues. Thanks to our world-class research infrastructure, Lund University is well equipped to help lead the way towards future scientific breakthroughs.

Below is a non-exhaustive list of in-house infrastructures that are categorized into three overarching themes: bio-imaging, proteins, genes & cells and other resources.


Bio-Imaging

Our facilities provide the opportunity to study molecules, cells, organs and entire organisms.


Proteins

With the help of various forms of mass spectrometry, synchrotron radiation, protein production & labelling, and bioinformatics, our facilities provide the opportunity to study protein structure and dynamics, molecular probes and drug design. Below you can see some examples of the infrastructure for proteins, available for researchers at Lund University.


Genes & Cells

Our facilities provide the opportunity to study molecular probes, system biology and molecular interactions in cells and tissues. Below you can see some examples of the infrastructure for research on genes and cells, available for researchers at Lund University.


Other resources

In addition to infrastructures for bioimaging, protein and genes & cells, we also provide other resources e.g., databases, networks and specialized labs.


List of infrastructures in alphabetical order


Anterior chamber of the eye (ACE) platform

Anterior chamber of the eye. Animation.

Direct visualization in a variety of tissues transplanted into the anterior chamber of the eye (ACE) provides a platform to screen drugs by performing long-term follow up and monitoring in target tissues. For access to competence and instruments please contact the ACE platform.


Adeno Associated Vector platform

AAV

Our Adeno-Associated Vector (AAV) platform offers development, design and production of AAV vectors. AAV vectors can be used for the establishment of disease models, experimental gene therapy and basic experimental research of brain functions. The AAV-facility is open to internal LU-users as well as external users from other universities and industry.

Read more: AAV Vector Lab


Biacore X100 - Surface Plasmon Resonance

 

Biacore X100. Photo.

The Biacore X100 instrument is open for external users to hire after completed course or we can provide a full service.

The Biacore X100 uses the surface plasmon resonance (SPR) technique to monitor molecular interactions in real time. The procedure is as follows; one of the interacting molecules (the ligand) is attached to a surface of a sensor chip, and the other interacting molecule (analyte) is injected and will flow over the sensor chip. If any binding occurs between the ligand and the analyte, the refractive index will change at the sensor surface, that is proportional to the change in mass concentration, and association and dissociation rates of the interaction may be determined.

Read more: Biacore X100- Surface Plasmon Resonance


BioMAX at MAX IV

Electron density map of the cofactor NADP bound to FabG. Courtesy of Robert Schnell, Karolinska Institutet
Electron density map of the cofactor NADP bound to FabG. Courtesy of Robert Schnell, Karolinska Institutet

BioMAX is the first X-ray macromolecular crystallography beamline of MAX IV Laboratory. It is a state-of-the-art resource accommodating multiple cutting edge experimental possibilities. The beamline experiment set-up is highly automated, in terms of both sample handling hardware and data analysis.

Due to its extensive energy tunability, BioMAX is an ideal source for de novo phasing using the anomalous signal of heavy elements. The small beam cross-section and parallel beam makes BioMAX suitable for X-ray crystallography using microcrystals and ultra large unit cells.

Read more: BioMAX at MAX IV


BioMS

 

BioMS flow chart

BioMS is a national research infrastructure supported by the Swedish Research Council with a mission to act as a Swedish hub for service, development and coordination of Biological Mass Spectrometry. Currently 40 technical experts, applications specialist and researchers are working in Lund, Stockholm and Gothenburg. The support is organized in two modules of operation, i.e. Quantitative and Structural MS.

Quantitative MS                                             

  • Large scale quantitative MS                            
  • Clinical proteomics                                                                      
  • Proteogenomics                                           
  • Targeted MS

Structural MS

  • Post translational modifications MS
  • Interaction MS     
  • Chemical proteomics

For more information visit our website or contact Lab Manager:

  • www.bioms.se
  • sven [dot] kjellstrom [at] med [dot] lu [dot] se (Lab Manager Sven Kjellström)

CBT Small Molecule Screening infrastructure

 


The CBT (Chemical Biology & Therapeutics) small molecule screening infrastructure enables the use of screening technology as well as expertise and reagents to help researchers at Lund University towards new discoveries in fundamental aspects of biology. The infrastructure is not limited to drug discovery but can be used by any researcher to quickly conduct hundreds of biochemical, genetic or pharmacological tests. The library contains annotated molecules with known biological activities, a powerful tool to identify novel mechanisms and pathways, several of the molecules are approved drugs or molecules that have been in the clinic, which might facilitate translation of early discoveries to human studies. In addition, included are also non-target biased commercial compounds and academic compounds, in total 10000 compounds.

Contact: Roger [dot] Olsson [at] med [dot] lu [dot] se


Cellomics and Flow Cytometry Core Facility at MultiPark

 

 

Screening/Analysis and FACSAria III are open to external users.
The Cellomics Array Scan is a high throughput system for acquisition and screening of Fluorescence Microscopy images, applying automated image analysis of fluorescence intensities in cells, subcellular compartments or small organisms, e.g. zebrafish and nematodes. Our BD FACSAriaIII cell sorter is equipped with three lasers (blue, yellow/green, red) and can analyze up to ten fluorescent channels and sort up to four cell populations simultaneously.

Read more: FACS platform at MultiPark and Cellomics platform at MultiPark


CCM - Centre for Comparative Medicine

The Centre for Comparative Medicine (CCM) is an infrastructure within the Medical Faculty at Lund University enabling researchers to carry out cutting edge translational research using animal models in Lund and Malmö.

Specialist veterinarians and geneticists are available to advise researchers on aspects of experimental design, ethical permit applications, animal health and husbandry, and advanced genetic engineering techniques. Skilled technical staff provide the daily care for around 35,000 animals (mostly rodents) and maintain the high levels of hygiene necessary to protect the animals. Swedish Animal Welfare regulations and 3R principles (Replacement, Reduction and Refinement) are followed strictly to ensure good animal welfare.

Read more: Centre for Comparative Medicine (CCM)


CLEM at IQ Biotechnology Platform

A scanning electron micrograph showing murine lung tissue.
A scanning electron micrograph showing murine lung tissue.

CLEM stands for Correlative Light and Electron Microscope (CLEM) that allows the simultaneous analysis of specimens by fluorescence and scanning electron microscopy. With this new technology, you can combine immunological and three-dimensional information within the same image. 

CLEM is the perfect tool to analyze unknown ultrastructures with a fast result, and to unravel complex relationships between structural and functional biological questions. We help you through the process, from preparation to analysis.

Read more: IQ Biotech Platform - CLEM


CTG - Center for Translational Genomics

dna animation.

CTG is a research infrastructure and technical platform for Next Generation Sequencing (NGS) and other genomics technologies. CTG is part of the SciLifeLab infrastructure. We provide the following services:

  • Support in project planning
  • Guidelines for DNA and RNA extractions
  • Quality control and Library preparation (standard and customized)
  • Next Generation Sequencing (DNA and RNA)
  • Bioinformatics expertise

Read more about CTG

 


CTP - Center for Translational Proteomics

 

Photo: CTP

The Center for Translational Proteomics (CTP) was established in 2018 and is financed by the Faculty of Medicine, Lund University and Region Skåne. CTP works closely with the Swedish national infrastructure for biological mass spectrometry (BioMS, Lund Node) supported by the Swedish Research Council.  CTP offers expertise and support in small proteomics and protein characterisation projects for scientists at the Faculty of Medicine, Lund University and Region Skåne. CTP helps with study design, mass spectrometry analysis (identification and quantification of proteins) and analysis of the data.

Contact: Charlotte [dot] Welinder [at] med [dot] lu [dot] se

Read more about CTP in the Lund University research portal


EpiHealth Cohort Study

crowd on street. photo.

EpiHealth cohort study is a national resource investigating the interaction between genes and life-style factors regarding the development of common diseases seen in the elderly. At present (2017) it includes 25,000 Swedish men and women between the ages of 45 and 75 years, new subjects are recruited continously. It is an open-access resource accessible for all researchers.

The aim of the study is to map the causes of our most common diseases, like heart and vascular disease, cancer, osteoporosis, depressions, diabetes, obesity, dementia etc. The study includes data of cardiovascular status, lung and cognitive function and biobanking, lifestyle factors and environmental exposure.

Read more: Epihealth Cohort Study


Health Science Lab (at the Health Sciences Center and Gerdahallen)

Young woman performs a physical test on an indoor exercise bike.

At Health Sciences Center you can test:

  • Muscular function, strength and endurance with Biodex
  • Muscular activity with EMG
  • Submaximal exercise capacity on ergometer cycles
  • Physical activity with accelerometers

At Gerdahallen you can test:

  • Maximal exercise and submaximal exercise capacity on ergometer cycles or treadmill incl. measurements with ergospirometer.
  • ECG or heart rate monitored with Polar pulse equipment.
  • Analyze of running technique

To book at Health Science lab, contact: andy [dot] andersson [at] med [dot] lu [dot] se

To book at Gerdahallen, contact: ulf [dot] malmsten [at] gerdahallen [dot] com


HistoCore Facility (HCF)

illustration SPTC CD56, CD3-15989

The HistoCore facility offers services for studying cells and tissue specimens of experimental animal and human origin. The purpose is to facilitate for researchers to connect to the pathology department and obtain well-annotated biobank samples for various omics analyses. The facility strives to interact with and increase the visibility of other similar facilities in the region of Malmö and Lund.

Services provided

The HistoCore facility provides services such as histoprocessing, paraffin embedding, paraffin sectioning, frozen sectioning, construction of tissue microarrays (TMA) and paraffin embedded cell blocks, immunohistochemistry,  and extraction of DNA/RNA from human and animal tissues, cells in culture and blood. We also provide services for slide scanning.

Contact: Bjorn [dot] nodin [at] med [dot] lu [dot] se


Image Core Facility at Immunology

advanced microscope. photo.

The Section of Immunology provides users with advanced microscopes, image analysis software and technical support. The core facility is available for researchers at Lund University.

The facility includes:

  • Laser scanning confocal (LSM700)
  • Zeiss Axiovision
  • TIRF/ Spinning disc FLIM Inverted microscope (6 laser lines)

Contact: Lena_M [dot] Svensson [at] med [dot] lu [dot] se


IQ Biotechnology Platform

Flowchart with various photos explaining the IQ Biotechnology Platform.

IQ Biotechnology gives you access to a whole spectrum of services from experimental design, to gene-, protein- and in vivo- experiments and all the way to analysis.  IQ Biotechnology do: Imaging and quantification, experimental design, assay development,high throughput experiments, validation, and data analysis:

  • Immunochistochemistry 
  • Light and Electron Microscopy (TEM, SEM and CLEM)
  • Cell analysis - BioPlex
  • Cytokine  - Biacore
  • Gene expression - qPCR 

Read more about: IQ Biotechnology


LBIC - Lund University Bioimaging Center

Illustration showing different imaging outputs

Lund University Bioimaging Centre, LBIC, is a national infrastructure that provides access to a large variety of advanced imaging equipment and cutting-edge bioimaging techniques, ranging from micro to macro. The overall goal is to help lead the way towards future scientific breakthroughs by enabling cutting-edge bioimaging techniques to be part of your research project!

Services

Dedicated and highly experienced staff scientists offer support throughout the entire experimental process – from study design to data handling. LBIC is also offering training, support, workshops and seminars. Our services are available to users from academia, industry and health care and regardless of your particular field of research, you are welcome to seek support from any of our facilities!

Equipment

The infrastructure is built up by several facilities covering all types of bioimaging research:

Microscopy

  • Confocal microscopes; wide-field fluorescence microscope and a combined TIRF/STORM (super resolution) microscope
  • Light sheet microscope
  • Automated live-cell imaging system (also in Biosafety Level 2 laboratory)
  • Transmission electron microscope (TEM)
  • Scanning electron microscope (SEM)

Preclinical Nuclear Medicine

  • μPET/CT
  • μSPECT/CT
  • Ultra-high resolution μCT

Preclinical MRI

  • MRI system, 9.4 Tesla
  • Advanced MRI analysis of data

Clinical MRI

  • MRI systems, 1,5 and 3 Tesla

The national 7Tesla Facility

  • Equipment for brain, knee, wrist, breast and abdominal imaging
  • fMRI stimuli and eye tracking
  • Clinical devices, such as contrast injector and ventilator

Analysis & Visualization

  • Image analysis software packages suitable for both small and large data sets
  • Software to transform imaging results into easy-to-use 3D surface models or ray-traced animations

Contact

If you are interested in using our services, please contact the person responsible for the facility of interest.

  • Microscopy: Lina Gefors, lina [dot] gefors [at] med [dot] lu [dot] se or
    Sebastian Wasserström, sebastian [dot] wasserstrom [at] med [dot] lu [dot] se
  • Preclinical Nuclear Medicine: Rita Gidlöf, ritha [dot] gidlof [at] med [dot] lu [dot] se
  • Preclinical MRI: René in 't Zandt, rene [dot] in_t_zandt [at] med [dot] lu [dot] se
  • Clinical MRI: Pia Sundgren, pia [dot] sundgren [at] med [dot] lu [dot] se
  • The National 7 Tesla Facility: Karin Markenroth Bloch, karin [dot] markenroth_bloch [at] med [dot] lu [dot] se
  • Analysis and Visualization: Jonas Ahlstedt, jonas [dot] ahlstedt [at] med [dot] lu [dot] se

For more information about available equipment, services or how to apply please visit: www.lbic.lu.se


 Life Science Microfluidics

Illustration microfluids infrastructure

The resource supports development of microfluidic systems. By enabling access to expertise in microfluidic system design and microfabrication facilities, this platform supports researchers with custom development and characterization of microfluidic devices. Our engineers are highly experienced in microfluidics and neuro-microtechnology as well as micromilling and 3D printing of microfluidic system components for many years and available to support microfluidic system development for a multitude of applications.

 Equipment and resources

  • Clean room facility for basic silicon and glass microfabrication as well as metal film deposition and patterning.
  • SU-8 photolithography.
  • High resolution direct laser exposure. Glass silicon anodic bonding.
  • PDMS microfabrication.
  • Precision CNC micromilling.
  • Polymer 3D-printing (Fused Filament Fabrication as well as laser induced polymerization).

Services provided

Life Science Microfluidics provides engineering support in research specific development of microfluidic solutions. Support includes device design and manufacturing as well as advice in device assembly and interconnecting to commercial system components (pumps, valves, flow control etc.) for full system functionality.

Contact

Anja Meissner anja [dot] meissner [at] med [dot] lu [dot] se
Thomas Laurell thomas [dot] laurell [at] bme [dot] lth [dot] se

LP3 - Lund Protein Production Platform

hands using automated pipette. Photo.

A cross-faculty facility for protein production and purification with:

  • Cloning - design of a vector construct
  • Protein production in bacterial cells and insect cells
  • Protein labelling
  • Protein purification using chromatography equipment

At LP3 we exchange scientific ideas for dissemination and assimilation of new methodologies for protein production, purification and analysis. We also offer research training and development of skills in experimental protein science for PhD students and postdocs.

Read more: LP3 - Lund Protein Production Platform


LUBI - Lund University Bioinformatics Infrastructure

LUBI illustration

Lund University Bioinformatics Infrastructure (LUBI) was established in the end of 2020 as an open research infrastructure/network for bioinformatics, accessible to all researchers and students interested in bioinformatics. The goal for LUBI is to strengthen and coordinate bioinformatics at Lund University. LUBI aims to increase the visibility of bioinformatics resources, organize seminars and workshops, and promote knowledge exchange.

Read more: LUBI - Lund University Bioinformatics Infrastructure


Injection of embryonic stem cells (ES-cells) into morula-stage embryos. Microscopy photo.
Injection of embryonic stem cells (ES-cells) into morula-stage embryos. Photo: L. Wei

The Lund University Transgenic Core Facility

The Lund University Transgenic Core Facility (LUTCF) is a facility whose primary goal is to deliver the most up-to-date methodologies in transgenic technology to Lund University’s researchers and even external users. 
 
The LUTCF offers the following services:

  • IVF or natural mating
  • ES morula/blastocyst injections
  • Sperm cryopreservation
  • Rederivation services
  • Strain expansion by IVF
  • Pronuclear DNA microinjections
  • Injection of CRISPR edited DNA

Please contact our experienced staff for advice and help with your transgenic project.
transgen [at] med [dot] lu [dot] se

Read more: The Lund University Transgenic Core Facility (LUTCF)


LUPOP (Lund University Population Research Platform)

Animated crowd in black, grey and blue.

LUPOP is an open resource available for all researchers at Lund University. LUPOP provides support for population based research, such as advice on study design and scientific approaches, applications for funding and data access within population research, and ethical and legal issues. Through the website www.lupop.lu.se, researchers and students can keep updated with the latest within population based research. The website can also be used by researchers at Lund University to provide information to colleagues, students, media, and the public.

Read more: www.lupop.lu.se


MAX IV

 

Foto: Leif Jansson
MAX IV by night
MAX IV by night

 

The MAX IV Laboratory serves 1000 users per year and deliver science in a broad range of fields including structure and dynamics of proteins in solution, protein crystallography and biomedical imaging. Since summer 2016 the new world leadning synchotron facility, MAX IV is up and running.

Read more: MAX IV


MedMAX a future part of the MAX IV Laboratory in Lund

 

MedMAX – a future beamline inside MAX IV, which will help us to study events and processes in tissues and materials using accelerators producing x-rays of very high intensity. MedMAX will be a super-eye capable of helping us understand biomedical problems. With its help, we can find new ways of discovering, diagnosing and treating diseases such as cancer, diabetes and osteoporosis.

Read more about the campaign: MedMAX

Read more about MedMAX


MESO QuickPlex at MultiPark Platform

mesoquick

The MESO QuickPlex is a multiplexing plate reader using high-performance, electrochemiluminescence (ECL) immunoassays for detecting bio markers.

It is quick (90 seconds for one plate) and can handle many samples at the same time. The ECL system allows for detection with high sensitivity and wide dynamic range, which in combination with multi-array technology enables accurate measurements of multiple analytes in low sample volume. The instrument is easy to learn and use. There is more than 600 immunoassays for a range of applications including immunology, inflammation, oncology, neurobiology, and toxicology, in various assay formats.

Read more: MESO QuickPlex at MultiPark Platform


 


Microscopy Community at Lund University (MiCLU)

bacteria. animation.

MiCLU is promoting imaging with a special focuson correlative 3D imaging with microscopy and microscopic analysisat Lund University. The main role of MiCLU is to provide planning for goodaccess at Lund University to advanced equipment and methods in microscopy andmicroscopic analysis. MiCLU works to promote co-ordination and synergismof existing infrastructure resources and planning and applications for newresources.

For more information visit MiCLU webpage


MoReLife

Two researchers looking at displays surrounded by technical equipment.

A network named Molecular Recognition in Life (MoReLife) which aims to promote development and coordination of competences of use to life science researchers at Lund University. MoReLife is a trans-disciplinary network distributed over the faculties of Science, Medicine and Engineering. The focus is molecular Life Science:

  • Bioimaging and in vivo models
  • Systems biology and omics
  • Molecular Probes and drug design
  • Protein structure and recognition

Read more: MoReLife


Optical Projection Tomography - OPT

Medical image from the OPT imaging platform showing organic tissue.
  • Do you want to create high-resolution 3D images of large specimen like mouse pancreas, liver, kidney, spinal cord or brain?
  • Do you want to aquire flourescent images and map the distribution of a flourescent protein/molecule of interest?

Then our expertise in OPT imaging could help you to answer your scientific question.

Read more: OPT imaging platform


The Scania Metadatabase for Epidemiology

Crowd. Photo.

The Scania Metadatabase of Epidemiology is a catalogue with a description of several of the epidemiological studies that have been collected within Lund University and Region Skåne. The catalogue currently comprises 50 studies including a total of more than 670 000 study participants, as well as biological samples from about 20 studies.

The expectation is that the metadatabase will be used as an inspiration for new research and open up new research partnerships by visualizing the research groups and their publications.

Contact: jonas [dot] bjork [at] med [dot] lu [dot] se


SpatialOmics@LU

SpatialOmics illustration

The SpatialOmics@LU facility at the department of Immunotechnology provides hi-plex, spatial expression analysis with the GeoMx DSP instrument. Investigate 1800+ RNA or up to 80 protein targets in specific regions of tissue sections defined by the morphology. The facility also offers targeted gene expression analysis of up to 800 targets with the nCounter system. Read more here: http://www.lth.se/spatialomicslu/

The department of Immunotechnology has several other infrastructures:http://www.immun.lth.se/infrastructure/


StemTherapy FACS Core Facility

Two women working controlling analysis machines at the Stem Therapy FACS lab.

Flow cytometry is one of the major methods used to analyze and sub-fractionate cells. It has major advantages such as the simultaneous detection of a wide range of parameters that enables the understanding of diversity among seemingly similar cells. The ability to enumerate large numbers of viable cells in a relatively short period of time provides experiment with reliability. At the Stem Therapy FACS Core Facility we have three cell FACS Aria sorters, that allow detection of up to 16 fluorescent probes, as well as two analysis machines: Fortessa and LSRII. We can help you through the whole process, from design of the experiment to the running of the experiment.

  • Assisted Cell sorting
  • Assisted FACS Analysis
  • Advice and supervision of users during experiments

Advice for experimental design and developing new protocols

Read more: StemTherapy FACS 


Tissue Micro Array Center

Kidney tissue stained with vimentin antibody.
Kidney tissue stained with vimentin antibody.

The TMA-center offers high quality immunohistochemistry staining of tissue. Sample preparation and processing, embedding, sectioning, staining and scanning of the stained slides. We provides both single staining (one protein) and double staining (two proteins) performed with an Autostainer (Agilent/DAKO) automated system. The stained slides are scanned using an Aperio scanner.

The TMA-center also assembles TMA-blocks. A TMA block (Tissue Micro Array) is a block consisting of small cores from up to 96 different samples/cancers/tissues all organized in one block.

Contact: kristina [dot] ekstrom-holka [at] skane [dot] se (Kristina Ekström-Holka)


Two-photon microscopy at BMC

Two people looking at screen. Photo.
Angela Cenci-Nilsson & Tim Fieblinger in the in vitro two-photon microscopy lab.

This platform allows imaging of tissues with very high temporal and spatial resolution. It consists of two microscopy stations: an ‘in vivo’ setup is used to image dynamic processes in the life mouse and an ‘ex vivo’ system designed to image thick live preparations, such as tissues that are not accessible to ‘in vivo’ microscopy. Both systems are available for LU and external users.

Read more: Two-photon-microscopy


Contact

Kajsa M Paulsson

Kajsa M Paulsson

Coordinator Research Infrastructure

e-mail: kajsa_m [dot] paulsson [at] med [dot] lu [dot] se